Gene expression profiling discriminates biopsies – in paediatric patients investigated for suspected celiac disease

Celiac disease (CD) is an inflammatory disease, triggered by an immunologic response to gluten in wheat, which manifests itself by symptoms such as diarrhoea, abdominal pain and malabsorption. CD results in an inflamed small intestine with varying degree of villous atrophy, crypt hyperplasia, increased intraepithelial lymphocytes and increased paracellular permeability of the intestinal epithelium. According to current guidelines, the diagnosis of CD requires intestinal biopsy and is set by histopathological findings. The aim of this study was to investigate the possibility of establishing molecular classifiers using gene expression data. Gene expression profiling discriminates biopsies – in paediatric patients investigated for suspected celiac disease